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CAS No.: 633-66-9

硫酸小檗碱 Catalog No. CSN21524

Synonyms: Natural Yellow 18 sulfate;Umbellatine Sulfate;小檗碱半硫酸盐

Berberine Hemisulfate is an alkaloid with relatively weak antibiotic properties for its efflux by multidrug resistance pumps.

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400-920-2911

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生物活性

描述Berberine Hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, and has long been used as an antibiotic. Berberine inhibited human colorectal adenocarcinoma (LoVo) cell growth in a time- and dose-dependent manner. A WST-1 assay showed that the IC50 value after 72 h was 40.79 ± 4.11 μM. Cell cycle analysis of 40 μM berberine-treated LoVo cells by flow cytometry showed accumulation of cells in the G2/M phase. Berberine at a dose of 50 mg kg(-1) day(-1) showed inhibitory rates of 45.3% in a human colorectal adenocarcinoma xenograft in nude mice^[1]. The Saccharomyces cerevisiae sod2Delta, a deletion mutant lacking Mn-SOD gene, was highly sensitive to berberine and veratraldehyde. Activity of strobilurin (25-50 micromol l(-1)) was elevated on most aspergilli and Penicillium expansum by co-application with berberine or veratraldehyde (2-4 mmol l(-1)) ^[2]. Moreover, berberine salts could be used as fluorescent materials, but proper choice of the anion allows using the self-association properties to best advantage^[3].
参考文献

[1] Cai Y, Xia Q, Luo R, et al. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 2014;68(1):53‐62
[2] Kim JH, Campbell BC, Mahoney N, Chan KL, Molyneux RJ, May GS. Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. Lett Appl Microbiol. 2007;45(2):134‐141
[3] Soulié M, Carayon C, Saffon N, Blanc S, Fery-Forgues S. A comparative study of nine berberine salts in the solid state: optimization of the photoluminescence and self-association properties through the choice of the anion. Phys Chem Chem Phys. 2016;18(43):29999‐30008

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3072 mL
- 11.5358 mL
- 23.0717 mL
- 5 mM
- 0.4614 mL
- 2.3072 mL
- 4.6143 mL
- 10 mM
- 0.2307 mL
- 1.1536 mL
- 2.3072 mL

技术信息

CAS号

633-66-9

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H19NO8S

运输

蓝冰

分子量

433.43

别名

Natural Yellow 18 sulfate;Umbellatine Sulfate;小檗碱半硫酸盐

溶解度

DMSO	21.0 mg/mL (48.5 mM) warming
Water	105.0 mg/mL (242.3 mM)

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